Human rhinovirus with antibodies
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Human rhinovirus with antibodies
Human rhinovirus (HRV) with antibody fragments, computer model. This image was created using molecular modelling software and data from cryo- electron microscopy. It shows the protein shell of the virus (white, grey and orange), known as the capsid, covered by antibody fragments (blue) known as Fab (antigen binding fragment). HRV is the virus that causes the common cold. Cryo-electron microscopes fire multi-angled beams of electrons at specimens that are kept at minus 150 degrees Celsius. The microscope collects slices of data that are reconstructed into 3-D models by computer
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6435083
© THOMAS SMITH/DANFORTH CENTER/SCIENCE PHOTO LIBRARY
3 D Electron Microscopy 3 D Visualisation 3 D Visualization Antibodies Antibody Antigen Capsid Common Cold Computer Graphic Computer Rendering Cryo Electron Cryo Electron Microscope Cryo Em Cryoelectron Microscopy Electron Cryomicroscopy Electron Microscopy Immune System Infectious Disease Macromolecular Macromolecule Modelling Molecular Imaging Particle Picornavirus Protein Shell Reconstruction Shape Structural Biology Surface Viral Shell Virion Virology Micro Biology Microbiological Molecular Model Molecular Structure Pathogen Protein Virus
EDITORS COMMENTS
This print showcases a computer-generated model of the human rhinovirus (HRV) along with antibody fragments, created using advanced molecular modelling software and data obtained from cryo-electron microscopy. The image provides a detailed visualization of the virus's protein shell, known as the capsid, depicted in shades of white, grey, and orange. Overlapping the capsid are striking blue antibody fragments called Fab (antigen binding fragment), which play a crucial role in immune responses. HRV is notorious for causing the common cold, making it an intriguing subject for scientific study. Cryo-electron microscopes were utilized to capture this image by firing beams of electrons at specimens maintained at an astonishingly low temperature of minus 150 degrees Celsius. These microscopes collect slices of data that are then reconstructed into three-dimensional models through computer algorithms. The visual representation presented here highlights key aspects related to HRV's structure and biology while emphasizing its interaction with antibodies within our immune system. This intricate interplay between pathogen and host is essential knowledge for researchers working towards developing effective treatments or preventive measures against viral infections like the common cold. By combining cutting-edge technology such as cryo-electron microscopy with molecular imaging techniques, scientists can unravel the mysteries behind viruses like HRV on a microscopic level. This remarkable fusion of science and artistry offers us invaluable insights into these minuscule yet impactful entities that shape our health and well-being.
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